Team

Ganna Panasyuk, PhD,HDR

I have obtained a PhD degree in Molecular biology from the Institute of Molecular biology and Genetics of National Academy of Sciences of Ukraine in Kyiv (Ukraine, 2006). In my graduate studies I was trained in the field of major growth regulator mTOR/PI3K/S6K signalling in the lab of Valeriy Filonenko (Institute of Molecular Biology and Genetics, Kyiv, Ukraine). It is through this graduate training and multiple collaborative visits to Ludwig Institute for Cancer Research in London that my long-lasting interest in the cross-talk between metabolism and signal transduction was ignited. I continued in postdoctoral studies in the lab of Ivan Gout at University College London in UK where I have discovered the novel splice form of mTOR kinase and demonstrated its relevance for cell proliferation. In 2009, I came to France to join the lab of Mario Pende at INSERM. This postdoctoral training has shaped my scientific interest in the mechanisms of metabolic control in physiology and its implication in human disease. I have secured an INSERM tenure position in 2013 following a highly competitive international recruitment procedure to develop my research program at the Institute Necker Enfants Malades in Paris. Today the research of my team is funded by French national start-up award for junior group leader (ANR JCJC) which I have obtained in 2016. I also hold a habilitation degree (HDR) from University Paris Descartes (2015) and currently I am involved in scientific mentoring programs at INEM and different French universities.


Muriel Girard, MD, PhD  

I obtained MD degree from Tours Medical School. Today, I am a practicing pediatrician in the Liver-Gastroenterology department in Necker Hospital. I am diagnosing and treating patients with severe liver disease and specializing in liver transplantation in children. I am convinced that to help these patients we must bring the molecular knowledge of the disease to their bedside. In 2011, I have obtained a PhD degree for my work on the genetic predisposition factors in rare liver diseases. I joined Ganna’s team in 2017 to develop a project aiming to unveil the genetic bases of rare liver diseases.


Catherine Caillaud, MD, PhD

I have obtained MD from Paris Descartes University followed by a certification in Genetics and Habilitation to Direct Research (HDR). Today, I teach as an Associate Professor in Genetics at Paris Descartes University and also head a diagnostic laboratory for lysosomal diseases at Necker Hospital. I am an active member of the Reference Center on Lysosomal Diseases (CRML) directed by Dr Bénédicte Héron in Paris and work in different French committees for the treatment of lysosomal diseases in France. I am a President of the Scientific Committee of the VML (Vaincre les Maladies Lysosomales) association. My basic research is focused on molecular characterization of lysosomal diseases, particularly ceroid lipofuscinoses. One of my achievements is the development of the first diagnosis methods for neuronal ceroid lipofuscinoses in France. Furthermore, I have directed the works on development of therapeutic methods (enzyme replacement therapy, chaperones, and mainly gene therapy) for other lysosomal disorders such as Pompe disease and Sandhoff disease. I joined Ganna’s team to contribute to a project aiming to unveil the genetic bases of lysosomal diseases with unknown etiology.


Anton Iershov, PhD, MSC Fellow, Campus de France PRESTIGE grant


I obtained my PhD degree from Institute of Molecular biology and Genetics of National Academy of Sciences of Ukraine in Kyiv (Ukraine, 2016). I was trained in the field of cancer signalling and focussed on the molecular mechanisms of glioma. In my work I love combining the experimenting on the bench and computational approaches. Keen to pursuit my postgraduate training, I moved to France in 2017 to join the team of Ganna as MSC Fellow to develop the postdoctoral project that aims to discover novel functions of class 3 PI3k signalling in control of cellular catabolism.


Chantal Alkhoury, PhD student, supported by Bulos Fundation

I obtained my MSc degree in cell biology at UPMC. It is during my MSc internship in lab of Francois Rouyer that I was awestruck by the knowledge-gaining powers of genetic models. During this training that I have got the first taste of organismal complexity and the supremacy of biological clocks assuring organismal homeostasis. In 2016, I have joined the team of Ganna to develop a PhD project under her mentorship in which I aim to unravel the complexity of class 3 pI3K signalling in metabolic control in liver.


Nate Henneman,  Master student, Paris Descartes University 

I obtained my BA from Bates College (Lewiston, Maine 2016). I was trained in the field of vision research at Emory University, throughout the summers of university and two years after graduating university. My previous research more specifically focused on retinal neurodegenerative disease models and how neuroprotective compounds can be used to prevent functional and morphological damage to the retina. I moved to Paris in September of 2018 to continue my studies in the form of a masters degree at University of Paris Descartes, specializing in molecular biology. I am very excited to work with Ganna and her team to learn more about how class 3 PI3K controls the metabolic demands of the cell.


Alexis Gadault, Assistant Engineer

I was graduated in 2016 from the University Paris Diderot with a MSc degree in cellular biology. It was preceded by studies in BTS (Biomedical Analysis) and Licence (Biomedical Research) at ESTBA in Paris. During my undergraduate studies, I did laboratory trainings which ignited my interest in translational research in the domain of immunology. That is why after graduation, as my first job as assistant engineer, I have joined the team of Immunology of Diabetes (Cochin Institute, Paris) where during two years I was instrumental in developing and characterisation of humanised mouse model of type 1 diabetes. Work on this project further matured my interest in biomedical research when we aim to understand the biological processes at molecular level to develop new therapies. I enjoy working as an engineer in a team of researchers as it presents me with the opportunities to contribute to different projects by establishing new techniques, tools and models. I particularly like to integrate data from different approaches that allow developing a better understanding of cellular functions or pathways. So far, I had a great experience with an autoimmune disease and I am looking forward to widen my professional horizons. With this in mind I have joined Ganna's Team to work on a new project that aims to decipher if and how defects in class 3 PI3K signalling in liver manifest in human disease. I am looking forward to apply my expertise in this team and, of course, to growth further professionally.


Alexandre Quesnoy, undergraduate trainee
I have joined Ganna’s team for a 2-month internship. I am a 2nd year engineer student in biotechnology at Sup’Biotech, Paris. I have a great interest in learning more about metabolism and signaling pathways as I consider working in this domain in future. Having been taught only general subjects at my school, I am looking forward to apply my theoretical knowledge of different techniques and learn more about biological processes in practice during this first professional experience. Upcoming two months, I will work with all members of the team and will learn in depth about their subjects. I am motivated to get familiar with as many as possible techniques that we use in the lab and to get firsthand experience about day-to-day life of the researchers.


Alumni 


MSc students:

2018


Edward Chalouhi, Master student, University Pierre and Marie Curie

I obtained my Biochemistry degree at Lebanese University and in 2017 I have moved to Paris to continue with my master studies. Today, I am pursuing my MSc training in Cell Biology at University Pierre et Marie Curie (UPMC) specialising in cell biology and signalling. In the team of Ganna I am passionate to learn about how class 3 PI3K controls lysosomal function. 

Camille Streiff, Master student, Diderot University

I am a 4th year medical student in Strasbourg Medical School. My ambition is to become a medical doctor-researcher. In 2017, I have moved to Paris and was accepted to highly competitive Master programme in Genetics at Diderot University. In Ganna’s team I am developing the project in which I aim to discover the genetic alterations in class 3 PI3K in human disease.

Sylvia MIRANDA, technicien trainee (ESTBA)


I am a last year laboratory engineer student at ESTBA. In 2017, I have joined the team of Ganna for a 6-month laboratory internship. I am teamed-up with all members and contribute to all on-going projects. I love working with mouse models and today my favourite technique is immunohistochemistry and quantitative PCR. I am looking forward to every week to learn new aspects of class 3 PI3K biology. 


Postdocs: Ivan Nemazanyy, current position: head of Necker Metabolic Facility (tenure)


PhD students: Cecilia Patitucci (PhD with honours, 2016), current position: postdoctoral researcher, Pasteur Institute, France

MSc students:

2017

Herve Abissa Kouakou (ESTBA)

Alix THOMAS (MSc, L’Université Paris Diderot-Paris 7)

Paola Guadagnuolo (Msc, L’Université Paris Diderot)

Ikram CHAHMI-GHEIDENE (M1, UPMC)

Anne-Cecile CHODKIEWIEZ (M1, UVSQ)

2016

Jeffie Lafosse (M1, UVSQ)

Martin Mathurin (M1, BCPP Paris Diderot)

Aissata Niasse (M1, UVSQ, M1)

2015

Julien Dorival (M1, UVSQ)

Salimata Magassa (M1, UPMC)

2014

Frank Ling (M2, UPMC)